2. Signaling Pathways
  3. Anti-infection
  4. Parasite
  5. Coccidia Isoform

Coccidia

The coccidia are obligate intracellular apicomplexan parasites that cause intestinal infection in humans. The most common coccidia to infect humans are Cyclospora cayetanensis and Cystoisospora belli (formerly Isospora belli).Infection with these parasites occurs through the fecal–oral route via ingestion of infectious oocysts in contaminated food or water. Following ingestion, the oocysts excyst and release sporozoites which infect epithelial cells of the small intestine, and occasionally the biliary tree. Cryptosporidium may also infect epithelial cells of other tissues including the respiratory tract. In the immunocompetent host, infection with any of these three parasites is commonly associated with self-limited watery diarrhea, nausea, vomiting, abdominal pain and low-grade fever.

Coccidia Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-15597
    Salinomycin
    		99.74%
    Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells.
  • HY-17008
    Toltrazuril (sulfone)
    		Inhibitor 98.59%
    Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.
  • HY-B2157
    Robenidine hydrochloride
    		Inhibitor 98.5%
    Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
  • HY-B0175
    Toltrazuril
    		Inhibitor 99.52%
    Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
  • HY-B0357
    Diclazuril
    		Inhibitor 99.70%
    Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
  • HY-106662
    Chloroquinoxaline sulfonamide
    		Inhibitor 99.06%
    Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.
  • HY-121410
    Narasin
    		Inhibitor ≥98.0%
    Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways.
  • HY-B1282A
    Sulfaquinoxaline sodium salt
    		Inhibitor 99.72%
    Sulfaquinoxaline sodium salt is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections.
  • HY-107814
    Nicarbazin
    		Inhibitor 99.64%
    Nicarbazin is an effective anticoccidial agent for chickens.
  • HY-19285A
    Sulfaclozine sodium
    		Inhibitor 99.02%
    Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
  • HY-B0937A
    Amprolium hydrochloride
    		Inhibitor 98.79%
    Amprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption.
  • HY-B1282
    Sulfaquinoxaline
    		Inhibitor 98.0%
    Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections.
  • HY-B1036
    Decoquinate
    		Inhibitor 99.26%
    Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry.
  • HY-19285
    Sulfaclozine
    		Inhibitor 99.0%
    Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
  • HY-B2157S
    Robenidine-d8 hydrochloride
    		Inhibitor 99.0%
    Robenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
  • HY-136438
    Toltrazuril sulfoxide
    		Inhibitor 99.55%
    Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
  • HY-B0357S
    Diclazuril-d4
    		Inhibitor 98.00%
    Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
  • HY-107814S
    Nicarbazin-d8
    		Inhibitor 99.99%
    Nicarbazin-d8 is deuterium labeled Nicarbazin. Nicarbazin is an effective anticoccidial agent for chickens.
  • HY-B1088
    Clopidol
    		Inhibitor 99.77%
    Clopidol (WR-61112) is an anticoccidial agent which is used as feed additive to control coccidiosis in chickens. Clopidol inhibits the sporulation of Eimeria tenella oocysts.
  • HY-B1004
    Dinitolmide
    		Inhibitor 99.66%
    Dinitolmide (Zoalene) is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella.